ACST-1 Long Term Follow-up

ACST-1 Long Term Follow-up


ACST-1 (ISRCTN26156392) is an international randomised trial. The aim of this trial is to find out whether carotid endarterectomy (CEA) and best medical treatment (BMT) together improve stroke-free survival time when compared to BMT alone. The study also aims to identify high-risk groups for whom the benefits of surgery and of BMT are increased. The long-term follow-up is looking at whether carotid endarterectomy reduces the risk of dementia.


Carotid stenosis is a condition where one or both of the carotid arteries (the main blood vessels that supply the head and neck) become narrowed due to a build-up of fatty deposits (plaque). This increases the risk of having a stroke, when the blood supply to part of the brain is cut off


Between 1993 and 2008 ASCT-1 included 3120 patients and is now looking at whether carotid endarterectomy reduces the risk of dementia. We will obtain information NHS electronic health records (ie, hospital admissions, out-patient and A&E attendances and death certificates) for UK ACST participants which will allow us to assess the long-term risk of stroke and dementia in this group of patients. This information will be held securely by The University of Oxford (Data Controller) and used solely for academic research purposes by the study team in Oxford. Importantly, whilst the information received is specific to each trial participant, no individual person will be identifiable in any publication arising from this work. To find out more about this long term follow up please see:


ACST-1 Long-term follow-up protocol


ACST-1 Long-term follow-up overview and contact details



This ACST-1 long-term follow-up study is funded by an Alzheimer’s Society project grant.


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