Link to previous randomisations



Online or over the phone

+44 (0) 1865 28 77 00


General queries

Tel: +44 (0)1865 61 79 79

UK Fax: +44 (0)1865 61 79 80


NICE encourages clinicians either to enter patients into the ACST-2 trial or to submit data to the Endovascular Carotid Register, run by the British Society of Interventional Radiology and the Vascular Society of Great Britain and Ireland.



Asymptomatic Carotid Surgery Trial (ACST-2)



ACST-2 (ISRCTN21144362) is an international randomised trial comparing carotid endarterectomy (CEA) with carotid stenting (CAS) for long-term stroke prevention.


Patients in ACST-2 have tight asymptomatic carotid stenosis. We are comparing both the immediate hazards of the procedures when carried out by experienced doctors and the subsequent stroke rates over the next 5 to 10 years.


Planned recruitment is 3,600 patients by the end of 2019 and we welcome new centres to participate in ACST-2. See the 'Investigator Section' for information about joining the trial.


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ACST-2 is supported by: