Asymptomatic Carotid Surgery Trial (ACST-2)



ACST-2 (ISRCTN21144362) is an international randomised trial, coordinated by The ACST-2 office at The University of Oxford, comparing carotid endarterectomy (CEA) with carotid stenting (CAS) for long-term stroke prevention.


Patients in ACST-2 have tight asymptomatic carotid stenosis. We are comparing both the immediate hazards of the procedures when carried out by experienced doctors and the subsequent stroke rates over the next 5 to 10 years.


Planned recruitment is 3,600 patients by the end of 2019 and we welcome new centres to participate in ACST-2. See the 'Investigator Section' for information about joining the trial.

Follow ACST-2




Link to previous randomisations



Online or over the phone

+44 (0) 1865 28 77 00


General queries

Tel: +44 (0)1865 61 79 79

UK Fax: +44 (0)1865 61 79 80


Copyright © 2011-2017 Nuffield Department of Surgical Sciences, John Radcliffe Hospital, Headington, Oxford, OX3 9DU

ACST-2 is supported by: